Symbol
Name
ID

Dicer1
dicer 1, ribonuclease type III
MGI:2177178

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Euthyroid multinodular goiter	Multinodular goiter	Thyroid carcinoma	Papillary thyroid carcinoma
Disease(s) Associated with DICER1
multinodular goiter

Mouse Phenotypes

increased Sertoli cell proliferation

abnormal thymus morphology

abnormal thymus development

abnormal thymus epithelium morphology

abnormal thymus cortex morphology

abnormal thymus medulla morphology

athymia

decreased thymocyte number

decreased endometrial gland number

decreased ovary weight

abnormal seminiferous tubule epithelium morphology

abnormal Sertoli cell morphology

ectopic Sertoli cells

small seminiferous tubules

seminiferous tubule degeneration

increased Leydig cell number

decreased testis weight

small testis

testis degeneration

abnormal thymus physiology

abnormal thymus involution

Availability

Mouse Genotype

Dicer1^tm1Bdh/Dicer1^tm1Bdh
Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ (conditional)

Dicer1^tm1Bdh/Dicer1^tm1Bdh
Amhr2^tm3(cre)Bhr/Amhr2⁺ (conditional)

Dicer1^tm1Bdh/Dicer1^tm1Bdh
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Dicer1^tm1Bdh/Dicer1^tm1Bdh
Defb41^{tm1(icre)Psip}/Defb41⁺ (conditional)

Dicer1^tm1Bdh/Dicer1^tm1Bdh
Tg(NEUROG3-cre)1Herr/0 (conditional)

Dicer1^tm1Mmk/Dicer1^tm1Mmk
Tg(Lck-cre)1Cwi/0 (conditional)

Dicer1^tm1Tara/Dicer1^tm1Tara
Foxn1^tm3(cre)Nrm/Foxn1⁺ (conditional)

Dicer1^tm1Bdh/Dicer1⁺
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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